"Can't Let Go" is a song written by American singer-songwriter Randy Weeks, made famous by Lucinda Williams in 1998–1999. Williams released "Can't Let Go" as a single from her album Car Wheels on a Gravel Road, and the song entered the Billboard Adult Alternative Airplay chart in December 1998, peaking at number 14 in March 1999, staying on the chart for 13 weeks. Williams earned a Grammy nomination for the song in the category Best Female Rock Vocal Performance.Weeks released his own version of the song in 2000, on his album Madeline.

In 2021, English singer Robert Plant and American singer/fiddler Alison Krauss covered the song on their album Raise the Roof. "Can't Let Go" was released as the lead single from the album, peaking at number 8 on the Adult Alternative Airplay chart.